Its getting late and I am tiered so "I'll will write this only once"
Every time I load this save game and open reserch screen I get CTD. It actually happened before on starting new turn but I was able to avoid it by changing research to different tech. Now I can't. I am not sure what is the reason, I might be simply running out of memory. Its been some time since I played map of this size. Usually I prefer one level smaller but I wanted to see how this one will work out with all technical improvement and I must say it works decently well considering my specs (i5 4th gen quad, 16gb ram) I wasn't going to report it at first but just in case it is a bug and you have nothing better to do, here you go 
save game link:
https://drive.google.com/file/d/1vpWm9ctpoI7pbFi2hI77NQZHOK1NwTd4/view?usp=sharing
Part of debug:
Enabled DLC:
Debug Message: DLC MapPack
Debug Message: DLC RegistrationBonus
Debug Message: DLC MegaEvents
Debug Message: DLC Snathi
Debug Message: DLC PrecursorWorlds
Debug Message: DLC Mercenaries
Debug Message: DLC BuildersKit
Debug Message: DLC RiseoftheTerrans
Debug Message: DLC LostTreasures
Debug Message: DLC AltarianProphecy
Debug Message: DLC Crusade
Debug Message: DLC MechKit
Debug Message: DLC Intrigue
Debug Message: DLC StarControlHeroes
Debug Message: DLC Retribution
Debug Message: DLC StarControlVillains
Debug Message: DLC WorldsInCrisis
Debug Message: DLCSystem finished loading data.
Debug Message: Save Version: 347 Original BUILD_VERSION_STRING: 4.0 Original BUILD_NUMBER: 10726
Debug Message: Save Version: 347 BUILD_VERSION_STRING: 4.0 BUILD_NUMBER: 10726
Debug Message: Save Original Platform: Steam
Debug Message: Game Loaded.
Debug Message: TachyonSystem: Attempting to send match report
Debug Message: TachyonSystem: Did not send match report due to CollectGameplayData option
Debug Message: StartGame 0.000000
DebugMessage: TemplateListBoxScrollBarVerticalSBSlider setting size 20 x 0
DebugMessage: DiplomacyReportStrengthsandWeaknessesScrollBarVerticalSBSlider setting size 20 x 0
DebugMessage: DiplomacyReportStrengthsandWeaknessesScrollBarVerticalSBSlider setting size 20 x 0
Debug Message: Popup Manager Update: Unhiding MainGameWnd
Debug Message: InitMapGfx Started...
Debug Message: InitMapGfx finished.
DebugMessage: TemplateListBoxScrollBarVerticalSBSlider setting size 20 x 0
Debug Message: Building tech tree for node: MasterEngineeringTech
Debug Message: Building tech tree for node: MasterColonizationTech
Debug Message: Cannot add modifier effect icon entry for Kiln of Worlds Complex, out of room.
Debug Message: Cannot add modifier effect icon entry for Kiln of Worlds Charge, out of room.
Debug Message: Cannot add modifier effect icon entry for Nanite Transmitter Complex, out of room.
Debug Message: Cannot add modifier effect icon entry for Nanite Transmitter Charge, out of room.
Debug Message: Cannot add modifier effect icon entry for Bernal Sphere Complex, out of room.
Debug Message: Cannot add modifier effect icon entry for Bernal Sphere Charge, out of room.
Debug Message: Cannot add modifier effect icon entry for Empathy Engine Complex, out of room.
Debug Message: Cannot add modifier effect icon entry for Empathy Engine Charge, out of room.
Debug Message: Building tech tree for node: MasterWarfareTech
Debug Message: Building tech tree for node: MasterCommunicationsTech
Debug Message: Send MainMapGfxEventTypeLoadingQueueTail
Debug Message: OnMainGameWndInitialize Handled
Debug Message: CSDFModelCore::LoadModelData has detected an SDF file that is an older version of SDF than expected: D:\@@ STEAM\steamapps\common\Galactic Civilizations III\Gfx\Models\Components\Meshes\ConstructionModel_WeaponTexture_A_01.sdf
Debug Message: CSDFModelCore::LoadModelData has detected an SDF file that is an older version of SDF than expected: D:\@@ STEAM\steamapps\common\Galactic Civilizations III\Gfx\Models\Components\Meshes\ConstructionModel_WeaponTexture_A_01.sdf
Debug Message: CSDFModelCore::LoadModelData has detected an SDF file that is an older version of SDF than expected: D:\@@ STEAM\steamapps\common\Galactic Civilizations III\Gfx\Models\Components\Meshes\ConstructionModel_WeaponTexture_A_01.sdf
Debug Message: CSDFModelCore::LoadModelData has detected an SDF file that is an older version of SDF than expected: D:\@@ STEAM\steamapps\common\Galactic Civilizations III\Gfx\Models\Components\Meshes\ConstructionModel_WeaponTexture_A_01.sdf
Debug Message: CSDFModelCore::LoadModelData has detected an SDF file that is an older version of SDF than expected: D:\@@ STEAM\steamapps\common\Galactic Civilizations III\Gfx\Models\Components\Meshes\ConstructionModel_WeaponTexture_A_01.sdf
Debug Message: CSDFModelCore::LoadModelData has detected an SDF file that is an older version of SDF than expected: D:\@@ STEAM\steamapps\common\Galactic Civilizations III\Gfx\Models\Components\Meshes\ConstructionModel_WeaponTexture_A_01.sdf
Debug Message: CSDFModelCore::LoadModelData has detected an SDF file that is an older version of SDF than expected: D:\@@ STEAM\steamapps\common\Galactic Civilizations III\Gfx\Models\Components\Meshes\ColonyModel_WeaponTexture_A_01.sdf
Debug Message: CSDFModelCore::LoadModelData has detected an SDF file that is an older version of SDF than expected: D:\@@ STEAM\steamapps\common\Galactic Civilizations III\Gfx\Models\Components\Meshes\ColonyModel_WeaponTexture_A_01.sdf
Debug Message: CSDFModelCore::LoadModelData has detected an SDF file that is an older version of SDF than expected: D:\@@ STEAM\steamapps\common\Galactic Civilizations III\Gfx\Models\Components\Meshes\ColonyModel_WeaponTexture_A_01.sdf
Debug Message: CSDFModelCore::LoadModelData has detected an SDF file that is an older version of SDF than expected: D:\@@ STEAM\steamapps\common\Galactic Civilizations III\Gfx\Models\Components\Meshes\SoldierModel_WeaponTexture_A_01.sdf
Debug Message: CSDFModelCore::LoadModelData has detected an SDF file that is an older version of SDF than expected: D:\@@ STEAM\steamapps\common\Galactic Civilizations III\Gfx\Models\Components\Meshes\ConstructionModel_WeaponTexture_A_01.sdf
Debug Message: CSDFModelCore::LoadModelData has detected an SDF file that is an older version of SDF than expected: D:\@@ STEAM\steamapps\common\Galactic Civilizations III\Gfx\Models\Components\Meshes\ConstructionModel_WeaponTexture_A_01.sdf
Debug Message: CSDFModelCore::LoadModelData has detected an SDF file that is an older version of SDF than expected: D:\@@ STEAM\steamapps\common\Galactic Civilizations III\Gfx\Models\Components\Meshes\ConstructionModel_WeaponTexture_A_01.sdf
Debug Message: CSDFModelCore::LoadModelData has detected an SDF file that is an older version of SDF than expected: D:\@@ STEAM\steamapps\common\Galactic Civilizations III\Gfx\Models\Components\Meshes\ConstructionModel_WeaponTexture_A_01.sdf
Debug Message: CSDFModelCore::LoadModelData has detected an SDF file that is an older version of SDF than expected: D:\@@ STEAM\steamapps\common\Galactic Civilizations III\Gfx\Models\Components\Meshes\ConstructionModel_WeaponTexture_A_01.sdf
Debug Message: CSDFModelCore::LoadModelData has detected an SDF file that is an older version of SDF than expected: D:\@@ STEAM\steamapps\common\Galactic Civilizations III\Gfx\Models\Components\Meshes\ConstructionModel_WeaponTexture_A_01.sdf
Debug Message: OnLoadingQueueTail 65.016235
Debug Message: OnInitializationComplete 1.452256
Debug Message: OnInitialized 0.001203
Debug Message: SetAITrigger
Debug Message: Started Skirmish
Debug Message: Start AI Process
Debug Message: DoActionAwardResearchAmount owner 6 amount 37000 tick 2
Debug Message: DoActionAwardResearchAmount owner 2 amount 32000 tick 2
Debug Message: ProcessInstantResearch pPlayerID 2
Debug Message: DoActionAwardResearchAmount owner 10 amount 49000 tick 17
Debug Message: ProcessInstantResearch pPlayerID 10
Debug Message: DoActionAwardResearchAmount owner 12 amount 56000 tick 24
Debug Message: ProcessInstantResearch pPlayerID 12
Debug Message: DoActionAwardResearchAmount owner 14 amount 55000 tick 194
Debug Message: DoActionAwardResearchAmount owner 16 amount 60000 tick 231
Debug Message: ProcessInstantResearch pPlayerID 16
Debug Message: DoActionAwardResearchAmount owner 18 amount 27000 tick 340
Debug Message: ProcessInstantResearch pPlayerID 18
Debug Message: DoActionAwardResearchAmount owner 22 amount 64000 tick 405
Debug Message: ProcessInstantResearch pPlayerID 22
Debug Message: DoActionAwardResearchAmount owner 24 amount 40000 tick 541
Debug Message: ProcessInstantResearch pPlayerID 24
Debug Message: DoActionAwardResearchAmount owner 26 amount 44000 tick 607
Debug Message: ProcessInstantResearch pPlayerID 26
Debug Message: Popup Manager Update: Unhiding ResearchContainerWnd