I decided to take a crack at an Insane-sized galaxy. I have been playing with Resource Frequency set to None in the options and up until now I assumed that it worked, that no strategic resources would generate.
But then I explored a bit and found one black hole with an Antimatter resource, and an asteroid field with a Durantium resource. Checked just now and my last settings used to start a new game include Resource Frequency set to None.