First of all I want to say that I absolutely loved the GalCivII, but here are some things I have noticed in this beta.
Now it's been awhile since I last played so I forgot a lot of stuff, THERES NO TUTORIAL!!!! So basically I have to try to remember how to play, I'm not sure how new people will learn how to play but there really needs to be a tutorial.
Also almost every time there was a loading screen it took about 3 minutes, it may not sound like a lot but it is a long loading screen and there is no way to tell if it is frozen or not.
Then when I went to pick which empire I wanted, the benefits and what not when I hovered over them some didn't fit in the little description box, the formatting was off, this also happened when I hovered over the different buildings I could build on my planets.
Since I have two monitors side by side, while the game is running I can move my mouse over to the right and my cursor goes onto my other monitor, this doesn't happen with other games that I play and it is very annoying.
Also there should be a mouse scroll, like put your cursor to the top of the screen and the screen will move instead of using the arrow keys every time. It would be much smoother with a mouse scroll.
And the game freezes.
And there was a lot of notable lag.
I have not tried multiplayer yet but I look forward to it.